Nuclear localization of senescence marker protein-30, SMP30, in cultured mouse Hepatocytes and its similarity to RNA polymerase

被引：27

作者：

Ishigami, A

Handa, S

Maruyama, N

Supakar, PC

机构：

[1] Inst Life Sci, Bhubaneswar 751023, Orissa, India

[2] Tokyo Metropolitan Inst Gerontol, Dept Mol Pathol, Itabashi Ku, Tokyo 1730015, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2003年 / 67卷 / 01期

关键词：

SMP30; nuclear localization;

D O I：

10.1271/bbb.67.158

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Senescence marker protein-30 (SMP30), expressed mostly in the liver, protects cells against various injuries by stimulating membrane calcium-pump activity. By immunohistochemistry and western blotting, we found that SMP30 was in both the nuclei and cytoplasm of cultured mouse hepatocytes. By a homology search, we found that a domain of the SMP30 sequence 51 amino acid residues long was 60-66% similar to bacterial and yeast RNA polymerases.

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收藏

页码：158 / 160

页数：3

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