CXCR4-mediated suppressor of cytokine signaling up-regulation inactivates growth hormone function

被引:17
作者
Garzón, R
Soriano, SF
Rodríguez-Frade, JM
Gómez, L
de Ana, AM
Sánchez-Gómez, M
Martínez, C
Mellado, M
机构
[1] Univ Autonoma Madrid, CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain
[2] Univ Nacl Colombia, Dept Chem, Lab Hormones, Bogota, Colombia
关键词
D O I
10.1074/jbc.M408010200
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Coordinated action between cytokines and chemokines is required for effective endocrine and immune responses. Proteins of both families promote receptor oligomerization, activation of the Janus kinase (JAK)/ STAT pathway, and transcription of many genes, including the suppressor of cytokine signaling ( SOCS) family. In this study, we show that chemokine-mediated SOCS1 and SOCS3 up-regulation modulates the signaling and function associated to a cytokine receptor, both in vitro and in vivo. The effect is mediated by SOCS binding to JAK2 and to the cytokine receptor, which blocks subsequent signaling events. The data reinforce the premise of cytokine-chemokine cross-talk, which helps contribute to modulating individual responses and in defining the functional plasticity of the immune system.
引用
收藏
页码:44460 / 44466
页数:7
相关论文
共 54 条
[1]   The chemokine SDF-1 is a chemoattractant for human CD34(+) hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34(+) progenitors to peripheral blood [J].
Aiuti, A ;
Webb, IJ ;
Bleul, C ;
Springer, T ;
GutierrezRamos, JC .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (01) :111-120
[2]   Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells [J].
Akdis, M ;
Verhagen, J ;
Taylor, A ;
Karamloo, F ;
Karagiannidis, C ;
Crameri, R ;
Thunberg, S ;
Deniz, G ;
Valenta, R ;
Fiebig, H ;
Kegel, C ;
Disch, R ;
Schmidt-Weber, CB ;
Blaser, K ;
Akdis, CA .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (11) :1567-1575
[3]   Suppressors of cytokine signalling (SOCS) in the immune system [J].
Alexander, WS .
NATURE REVIEWS IMMUNOLOGY, 2002, 2 (06) :410-416
[4]   Posttraumatic inflammation is a complex response based on the pathological expression of the nervous, immune, and endocrine functional systems [J].
Aller, MA ;
Arias, JL ;
Nava, MP ;
Arias, J .
EXPERIMENTAL BIOLOGY AND MEDICINE, 2004, 229 (02) :170-181
[5]   COMPARISON OF ACID ETHANOL EXTRACTION AND ACID GEL-FILTRATION PRIOR TO IGF-I AND IGF-II RADIOIMMUNOASSAYS - IMPROVEMENT OF DETERMINATIONS IN ACID ETHANOL EXTRACTS BY THE USE OF TRUNCATED IGF-I AS RADIOLIGAND [J].
BANG, P ;
ERIKSSON, U ;
SARA, V ;
WIVALL, IL ;
HALL, K .
ACTA ENDOCRINOLOGICA, 1991, 124 (06) :620-629
[6]   Monoclonal antibodies to growth hormone (GH) prolong liver GH binding and GH-induced IGF-I/IGFBP-3 synthesis [J].
Beauloye, V ;
Muaku, SM ;
Lause, P ;
Portetelle, D ;
Renaville, R ;
Robert, AR ;
Ketelslegers, JM ;
Maiter, D .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1999, 277 (02) :E308-E315
[7]   A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) [J].
Bleul, CC ;
Fuhlbrigge, RC ;
Casasnovas, JM ;
Aiuti, A ;
Springer, TA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (03) :1101-1109
[8]   The two NF-κB activation pathways and their role in innate and adaptive immunity [J].
Bonizzi, G ;
Karin, M .
TRENDS IN IMMUNOLOGY, 2004, 25 (06) :280-288
[9]   Age- and irradiation-associated loss of bone marrow hematopoietic function in mice is reversed by recombinant human growth hormone [J].
Carlo-Stella, C ;
Di Nicola, M ;
Milani, R ;
Longoni, P ;
Milanesi, M ;
Bifulco, C ;
Stucchi, C ;
Guidetti, A ;
Cleris, L ;
Formelli, F ;
Garotta, G ;
Gianni, AM .
EXPERIMENTAL HEMATOLOGY, 2004, 32 (02) :171-178
[10]  
CHAPPEL S, 2002, CYTOKINE REFERENCE, P251