Expression of glucose transporter and glucose uptake in human oocytes and preimplantation embryos

被引:59
作者
Dan-Goor, M
Sasson, S
Davarashvili, A
Almagor, M
机构
[1] Bikur Holim Hosp, Dept Obstet & Gynecol, IVF & Fertil Lab, IL-91004 Jerusalem, Israel
[2] Hebrew Univ Jerusalem, Sch Med, Dept Pharmacol, IL-91010 Jerusalem, Israel
关键词
glucose transporter; glucose uptake; GLUT-1; oocytes; preimplantation embryos;
D O I
10.1093/humrep/12.11.2508
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The expression of glucose transporters 1, 2, 3 and 4 was evaluated in human oocytes and polyploid preimplantation embryos. Only glucose transporter 1 (GLUT-1) isoform was detected in oocytes and in 2-12-cell stage embryos. Glucose uptake was markedly increased in embryos as compared to oocytes (19.7 +/- 3.4 pmol/min/embryo and 2.3 +/- 0.3 pmol/min/oocyte), and GLUT-1 was inhibited by cytochalasin B. These results suggest that, although GLUT-1 is expressed in human oocytes and throughout preimplantation development, its function in mediating the rise in glucose uptake is triggered following fertilization.
引用
收藏
页码:2508 / 2510
页数:3
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