Interactions of β-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's disease

被引：48

作者：

Ahn, Hyung J. ^{[1
]}

Chen, Zu-Lin ^{[1
]}

Zamolodchikov, Daria ^{[2
]}

Norris, Erin H. ^{[1
]}

Strickland, Sidney ^{[1
]}

机构：

[1] Rockefeller Univ, Patricia & John Rosenwald Lab Neurobiol & Genet, 1230 York Ave, New York, NY 10065 USA

[2] Regeneron Pharmaceut, Tarrytown, NY USA

来源：

CURRENT OPINION IN HEMATOLOGY | 2017年 / 24卷 / 05期

关键词：

beta-amyloid peptide; Alzheimer's disease; factor XII; fibrinogen; CEREBROSPINAL-FLUID; PRECURSOR PROTEIN; NERVOUS-SYSTEM; PLASMA-PROTEIN; CONTACT SYSTEM; BRAIN; ACTIVATION; BINDING; BIOMARKERS; ROLES;

D O I：

10.1097/MOH.0000000000000368

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Purpose of review To review the evidence that the Alzheimer peptide beta-amyloid interacts with the blood coagulation system and influences the pathophysiology of the disease. Recent findings beta-amyloid can interact with fibrinogen and blood coagulation factor XII and trigger ischemia and inflammation. Summary beta-amyloid interacts with fibrinogen and factor XII. These interactions can lead to increased clotting, abnormal clot formation, persistent fibrin deposition, and generation of proinflammatory molecules. These events can damage neurons and could contribute to the cognitive decline in Alzheimer's disease patients.

引用

页码：427 / 431

页数：5

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