Selection of criteria for comparing and evaluating the optimization of separation in ion chromatography

Optimization procedures in Ion Chromatography require unambiguous goals. Optimization criteria express such goals in mathematical terms. If the retention factor t(R), varies as a function of the parameters to be optimized, criteria should be selected that enable simultaneous optimization of retention and selectivity. The non - suppressed Ion Chromatographic method with conductometric detection is described for simultaneous determination of six inorganic anions: fluoride, chloride, nitrite, bromide, nitrate, and sulphate. It is demonstrated that the result of the optimization process depends on the optimization criterion selected. The computer-simulated chromatograms were used for the comparison of optima calculated using four different criteria. General recommendations for double criteria optimization of separation in ion chromatography are suggested.