18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies

被引：76

作者：

Hu, XS

Okamura, N

Arai, H ^{[1
]}

Higuchi, M

Matsui, T

Tashiro, M

Shinkawa, M

Itoh, M

Ido, T

Sasaki, H

机构：

[1] Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan

[2] Tohoku Univ, Ctr Cyclotron & Radioisotope, Sendai, Miyagi 9808574, Japan

来源：

NEUROLOGY | 2000年 / 55卷 / 10期

关键词：

D O I：

10.1212/WNL.55.10.1575

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Using F-18-fluorodopa PET and a constant 0.0062 influx rate in the putamen, dementia with Lewy bodies (n = 7) was distinguished from AD (n = 10) with a sensitivity of 86% and a specificity of 100%. A constant 0.0071 influx rate in the caudate yielded a sensitivity of 71% and a specificity of 100% for distinction of the two disorders. Despite a limited sample size, these findings suggest that assessing nigrostriatal dopaminergic function with F-18-fluorodopa PET may be a useful diagnostic aid in cases of dementia with Lewy bodies while patients are alive.

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页码：1575 / 1576

页数：2

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