Cation-chloride cotransporters in neuronal communication

被引：193

作者：

Delpire, E

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Anesthesiol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr, Dept Physiol & Mol Biophys, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Med Ctr, Ctr Mol Neurosci, Nashville, TN 37232 USA

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2000年 / 15卷

关键词：

D O I：

10.1152/physiologyonline.2000.15.6.309

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Two isoforms of the cation-Cl- cotransporter family are expressed in neurons and modulate neurotransmission. NKCC1, a Na+-K+-2Cl(-) cotransporter, by raising internal Cl-, is responsible for excitatory GABAergic activity in immature brain and in adult sensory neurons. KCC2, a neuronal-specific isoform of the K+-Cl- cotransporter, by lowering internal Cl- is critical for inhibitory GABA responses in mature central nervous system neurons.

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页码：309 / 312

页数：4

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