The progression of hepatitis B- and C-infections to chronic liver disease and hepatocellular carcinoma: epidemiology and pathogenesis

被引：37

作者：

Hayashi, PH ^{[1
]}

Di Bisceglie, AM ^{[1
]}

机构：

[1] St Louis Univ, Ctr Liver, Dept Internal Med, Div Gastroenterol & Hepatol, St Louis, MO 63110 USA

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2005年 / 89卷 / 02期

关键词：

D O I：

10.1016/j.mcna.2004.08.014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hepatocellular carcinoma (HCC) is a relatively common cancer worldwide. Chronic viral hepatitis, with progression to cirrhosis, remains the predominant risk factor for HCC. Although most HCC cases arise in hepatitis B-endemic areas outside North America, the United States is experiencing a significant rise in cases associated with cirrhosis from hepatitis C. This article reviews the link between chronic viral hepatitis B and C and HCC. Advances in the understanding of HCC epidemiology, pathogenesis, clinical presentation, prevention, screening, and treatment are reviewed.

引用

页码：371 / +

页数：20

共 71 条

[1] The prevalence of hepatitis C virus infection in the United States, 1988 through 1994 [J].

Alter, MJ ;

Kruszon-Moran, D ;

Nainan, OV ;

McQuillan, GM ;

Gao, FX ;

Moyer, LA ;

Kaslow, RA ;

Margolis, HS .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (08) :556-562

[2] National Institutes of Health Consensus Development Conference Statement: Management of hepatitis C: 2002 - June 10-12, 2002 [J].

不详 .

HEPATOLOGY, 2002, 36 (05) :S3-S20

[3]

BEASLEY RP, 1988, CANCER, V61, P1942, DOI 10.1002/1097-0142(19880515)61:10<1942::AID-CNCR2820611003>3.0.CO

[4]

2-J

[5] INCIDENCE OF HEPATITIS-B VIRUS-INFECTIONS IN PRESCHOOL-CHILDREN IN TAIWAN [J].

BEASLEY, RP ;

HWANG, LY ;

LIN, CC ;

LEU, ML ;

STEVENS, CE ;

SZMUNESS, W ;

CHEN, KP .

JOURNAL OF INFECTIOUS DISEASES, 1982, 146 (02) :198-204

[6]

BEASLEY RP, 1981, LANCET, V2, P1129

[7] An algorithm for the grading of activity in chronic hepatitis C [J].

Bedossa, P ;

Poynard, T .

HEPATOLOGY, 1996, 24 (02) :289-293

[8]

BEEBE GW, 1991, ADV APPL BIOTECHNOLO, P3

[9] Molecular viral oncology of hepatocellular carcinoma [J].

Block, TM ;

Mehta, AS ;

Fimmel, CJ ;

Jordan, R .

ONCOGENE, 2003, 22 (33) :5093-5107

[10] A NEW ANTIGEN IN LEUKEMIA SERA [J].

BLUMBERG, BS ;

ALTER, HJ ;

VISNICH, S .

JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1965, 191 (07) :541-&

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