Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor γ/retinoid x receptor pathway

被引：275

作者：

Kanayama, T

Kobayashi, N

Mamiya, S

Nakanishi, T

Nishikawa, J ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Dept Environm Biochem, Osaka, Japan

[2] Osaka Univ, Grad Sch Pharmaceut Sci, Dept Toxicol, Osaka, Japan

来源：

MOLECULAR PHARMACOLOGY | 2005年 / 67卷 / 03期

关键词：

D O I：

10.1124/mol.104.008409

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nuclear receptors play important roles in the maintenance of the endocrine system, regulation of organ differentiation, and fetal development. Endocrine disruptors exert their adverse effects by disrupting the endocrine system via various mechanisms. To assess the effects of endocrine disruptors on nuclear receptors, we developed a high-throughput method for identifying activators of nuclear receptors. Using this system, we found that triphenyltin and tributyltin were activators of peroxisome proliferator-activated receptor (PPAR) gamma and retinoid X receptor. Because PPARgamma is a master regulator of adipocyte differentiation, we assessed the effect of organotin compounds on preadipocyte 3T3-L1 cells. We found that organotin compounds stimulated differentiation of 3T3-L1 cells as well as expression of adipocyte marker genes.

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页码：766 / 774

页数：9

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