Striking effect of hydroxamic acid substitution on the phosphodiesterase type 4 (PDE4) and TNFα inhibitory activity of two series of rolipram analogues:: Implications for a new active site model of PDE4

被引：62

作者：

Kleinman, EF ^{[1
]}

Campbell, E ^{[1
]}

Giordano, LA ^{[1
]}

Cohan, VL ^{[1
]}

Jenkinson, TH ^{[1
]}

Cheng, JB ^{[1
]}

Shirley, JT ^{[1
]}

Pettipher, ER ^{[1
]}

Salter, ED ^{[1
]}

Hibbs, TA ^{[1
]}

DiCapua, FM ^{[1
]}

Bordner, J ^{[1
]}

机构：

[1] Pfizer Inc, Div Cent Res, Groton, CT 06340 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1998年 / 41卷 / 03期

关键词：

D O I：

10.1021/jm970685m

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：266 / 270

页数：5

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