The ETS domain transcription factor Elk-1 regulates the expression of its partner protein, SRF

被引：34

作者：

Kasza, A ^{[1
]}

O'Donnell, A ^{[1
]}

Gascoigne, K ^{[1
]}

Zeef, LAH ^{[1
]}

Hayes, A ^{[1
]}

Sharrocks, AD ^{[1
]}

机构：

[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2005年 / 280卷 / 02期

关键词：

D O I：

10.1074/jbc.M411161200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ternary complex factors (TCF) are a subfamily of ETS domain transcription factors that bind and activate serum response elements (SREs) in the promoters of target genes in a ternary complex with a second transcription factor, serum response factor (SRF). Here, we have identified the SRF gene as a target for the TCFs, thereby providing a positive feedback loop whereby TCF activation leads to the enhancement of the expression of its partner protein SRF. The binding of the TCF Elk-1 to the SRF promoter and subsequent regulation of SRF expression occurs in a ternary complex-dependent manner. Our data therefore reveal that SRF is an important target for the ERK and Rho signaling pathways that converge on a ternary TCF-SRF complex at the SRE on the SRF promoter.

引用

页码：1149 / 1155

页数：7

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