MR spectroscopy study of dichloroacetate treatment after ischemic stroke

被引：14

作者：

Graham, GD

Barker, PB

Brooks, WM

Morris, DC

Ahmed, W

Bryniarski, E

Hearshen, DO

Sanders, JA

Holshouser, BA

Turkel, CC

机构：

[1] Vet Adm Med Ctr, Albuquerque, NM 87108 USA

[2] Univ New Mexico, Albuquerque, NM 87131 USA

[3] Henry Ford Hosp, Detroit, MI 48202 USA

[4] Loma Linda Univ, Loma Linda, CA 92350 USA

[5] Cypros Pharmaceut Corp, Carlsbad, CA USA

来源：

NEUROLOGY | 2000年 / 55卷 / 09期

关键词：

D O I：

10.1212/WNL.55.9.1376

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In a double-blind, placebo-controlled study, we used H-1 MR spectroscopy to assess the effect of a single infusion of sodium dichloroacetate on lesion lactate 1 to 5 days after ischemic stroke. Apparent trends toward a reduction in lactate/N-acetyl compound ratios were seen at the higher drug doses employed, and in patients treated in the first 2 days following infarction. Use of spectroscopic measures as endpoints is feasible in acute stroke clinical trials.

引用

页码：1376 / 1378

页数：3

共 10 条

[1]

Brooks WM, 1999, MAGNET RESON MED, V41, P193, DOI 10.1002/(SICI)1522-2594(199901)41:1<193::AID-MRM27>3.0.CO

[2]

2-P

[3] EFFECT OF DICHLOROACETATE ON RECOVERY OF BRAIN LACTATE, PHOSPHORUS ENERGY METABOLITES, AND GLUTAMATE DURING REPERFUSION AFTER COMPLETE CEREBRAL-ISCHEMIA IN RATS [J].