Control mechanism of JAK/STAT signal transduction pathway

被引：148

作者：

Yamada, S

Shiono, S

Joo, A

Yoshimura, A

机构：

[1] Mitsubishi Electr Corp, Adv Technol R&D Ctr, Amagasaki, Hyogo 6618661, Japan

[2] Kyushu Univ, Med Inst Bioregulat, Higashi Ku, Fukuoka 8128582, Japan

来源：

FEBS LETTERS | 2003年 / 534卷 / 1-3期

关键词：

interferon-gamma; Janus kinase; signal transducer and activator of transcription; suppressor of cytokine signaling-1; nuclear tyrosine phosphatase;

D O I：

10.1016/S0014-5793(02)03842-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Suppressor of cytokine signaling-1 (SOCS1) was identified as the negative regulator of Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signal transduction pathway. However, the kinetics and control mechanism of the pathway have not yet been fully understood. We have developed the computer simulation of the JAK/STAT pathway. Without nuclear phosphatase, SOCS1's binding to JAK did not cause the decrease in nuclear phosphorylated STAT1. However, without SH2 domain-containing tyrosine phosphatase 2 (SHP-2) or cytoplasmic phosphatase, it did. So nuclear phosphatase is considered to be the most important in this system. By changing parameters of the model, dynamical characteristics and control mechanism were investigated. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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页码：190 / 196

页数：7

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