Vertebral fractures in boys with Duchenne muscular dystrophy

被引：76

作者：

Bothwell, JE ^{[1
]}

Gordon, KE ^{[1
]}

Dooley, JM ^{[1
]}

MacSween, J ^{[1
]}

Cummings, EA ^{[1
]}

Salisbury, S ^{[1
]}

机构：

[1] Royal Belfast Hosp Sick Children, Belfast BT12 6BE, Antrim, North Ireland

来源：

CLINICAL PEDIATRICS | 2003年 / 42卷 / 04期

关键词：

D O I：

10.1177/000992280304200408

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

Osteoporosis causes significant morbidity for boys with Duchenne muscular dystrophy. Corticosteroid therapy given to prolong mobility may increase the rate of osteoporosis and risk of fracture. This study of 33 boys with Duchenne muscular dystrophy determined retrospectively the incidence of vertebral fractures particularly after initiation of corticosteroids. A latency period of 40 months after commencement of steroids occurred before the first vertebral fracture appeared. However, by 100 months of treatment approximately 75% had sustained a vertebral fracture.

引用

页码：353 / 356

页数：4

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