Chemical ionization of neutral peptides produced by matrix-assisted laser desorption

被引：21

作者：

Belov, ME ^{[1
]}

Myatt, CP

Derrick, PJ

机构：

[1] Univ Warwick, Inst Mass Spectrometry, Coventry CV4 7AL, W Midlands, England

[2] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

CHEMICAL PHYSICS LETTERS | 1998年 / 284卷 / 5-6期

关键词：

D O I：

10.1016/S0009-2614(97)01448-6

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The cationization in the gas phase of neutral peptides formed under the conditions of matrix-assisted laser desorption (MALD) has been demonstrated. The beam of neutral peptides formed by MALD using one laser was intercepted several hundred micrometers above the sample surface by a beam of cations produced using a second laser. The intensity of cationized neutral gramicidin S formed in this way was comparable to the ion signal produced by conventional matrix-assisted laser desorption/ionization (MALDI). The threshold fluences for MALD of neutral peptides have been shown to be lower than those for formation of ions from the same samples by MALDI. (C) 1998 Elsevier Science B.V.

引用

页码：412 / 418

页数：7

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