Carriage of N-lactamica in a population at high risk of meningococcal disease

被引:16
作者
Simmons, G
Martin, D
Stewart, J
Bremner, D
机构
[1] Auckland Healthcare Publ Hlth Protect, Auckland, New Zealand
[2] ESR, Communicable Dis, Porirua, New Zealand
[3] Univ Auckland, HRC Biostat Unit, Auckland 1, New Zealand
[4] Univ Auckland, Dept Mol Med, Auckland 1, New Zealand
[5] Univ Auckland, Auckland Publ Hosp, Dept Microbiol, Auckland 1, New Zealand
关键词
D O I
10.1017/S095026889900415X
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Carriage of Neisseria lactamica among household contacts of meningococcal disease (MCD) cases was investigated during an epidemic in Auckland, New Zealand. The overall carriage rate for N. lactamica was 10.5 % (95 % CI 7.4-13.5 %) with a peak carriage rate in 2-year-olds of 61.5 % (95 % CI 26.6-88.1%). Factors associated with a significant (P < 0.05) increase in the likelihood of carriage included runny nose, the number of people per bedroom and youth. Genetic analysis of isolates revealed a striking correlation of strains within the same household but a high level of diversity between households, suggesting that household contact is an important factor in acquisition. For household contacts aged less than 5 years, there was a higher rate of carriage amongst those in contact with MCD cases under 8 years old than for contacts of cases aged 8 years and over. It is likely that development of MCD is a reflection of the nature and intensity of the exposure to a virulent strain of N. meningitidis, coupled with an absence of host resistance among those individuals not carrying N. lactamica.
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页码:99 / 104
页数:6
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