Group B streptococcal conjugate vaccines

被引:96
作者
Baker, CJ [1 ]
Edwards, MS [1 ]
机构
[1] Baylor Coll Med, Dept Pediat, Infect Dis Sect, Houston, TX 77030 USA
关键词
D O I
10.1136/adc.88.5.375
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Linkage of bacterial capsular polysaccharides to proteins to create conjugate vaccines has had a dramatic impact on the health of children. Although unconjugated polysaccharides are poorly immunogenic in infants and some older children and adults, their covalent coupling with proteins stimulates T cell dependent antigenic recognition that profoundly enhances immunogenicity. In the decade since the introduction and widespread use of Haemophilus influenzae type b polysaccharide conjugate vaccines in the United States, invasive H influenzae infections have become a rarity in childhood.(1) Similarly, the conjugation of polysaccharides of Streptococcus pneumoniae to a derivative of diphtheria toxoid and the addition of pneumococcal conjugate vaccine to infant immunisation schedules carries with it promise for a similar decline in the incidence of invasive pneumococcal disease in paediatric patients(2).
引用
收藏
页码:375 / 378
页数:4
相关论文
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