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Synthesis of 2′-deoxy-2′-[18F]fluoro-β-D-arabinofuranosyl nucleosides, [18F]FAU, [18F]FMAU, [18F]FBAU and [18F]FIAU, as potential PET agents for imaging cellular proliferation -: Synthesis of [18F]labeled FAU, FMAU, FBAU, FIAU

被引：107
作者：
Mangner, TJ
Klecker, RW
Anderson, L
Shields, AF
机构：
[1] Wayne State Univ, Childrens Hosp Michigan, PET Ctr, Detroit, MI 48201 USA
[2] US FDA, Lab Clin Pharmacol, Rockville, MD 20857 USA
[3] Wayne State Univ, Karmanos Canc Inst, Detroit, MI 48201 USA
来源：
NUCLEAR MEDICINE AND BIOLOGY | 2003年 / 30卷 / 03期
关键词：
fluorine-18; 2 '-[F-18]fluoro-2 '-deoxy-beta-D-arabinofuranosyl nucleosides; FAU; FMAU; FBAU; FIAU;
D O I：
10.1016/S0969-8051(02)00445-6
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
An efficient and reliable synthesis of 2'-deoxy-2'-[F-18]fluoro-beta-D-arabinofuranosyl nucleosides is presented. Overall decay-corrected radiochemical yields of 35-45% of 4 analogs, FAU, FMAU, FBAU and FIAU are routinely obtained in >98% radiochemical purity and with specific activities of greater than 3 Ci/mumol (110 MBq/mumol) in a synthesis time of approximately 3 hours. When similar to220 mCi (8.15 GBq) of starting [F-18]fluoride is used, 25-30 mCi (0.93-1.11 GBq) of product (enough to image two patients sequentially) is typically obtained. (C) 2003 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：215 / 224
页数：10
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