Autophagy defends cells against invading group a Streptococcus

被引：943

作者：

Nakagawa, I

Amano, A

Mizushima, N

Yamamoto, A

Yamaguchi, H

Kamimoto, T

Nara, J

Funao, J

Nakata, M

Tsuda, K

Hamada, S

Yoshimori, T

机构：

[1] Osaka Univ, Grad Sch Dent, Dept Oral & Mol Microbiol, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Dent, Dept Oral Frontier Biol, Suita, Osaka 5650871, Japan

[3] Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan

[4] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama 3320012, Japan

[5] Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Bunkyo Ku, Tokyo 1138613, Japan

[6] Nagahama Inst Biosci & Technol, Fac Biosci, Dept Cell Biol, Nagahama, Shiga 5260829, Japan

[7] Natl Inst Genet, SOKENDAI, Dept Cell Genet, Mishima, Shizuoka 4118540, Japan

来源：

SCIENCE | 2004年 / 306卷 / 5698期

关键词：

D O I：

10.1126/science.1103966

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We found that the autophagic machinery could effectively eliminate pathogenic group A Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the cytoplasm, GAS became enveloped by autophagosome-like compartments and were killed upon fusion of these compartments with lysosomes. In autophagy-deficient Atg5(-/-) cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens.

引用

页码：1037 / 1040

页数：4

共 20 条

[1] Molecular basis of group A streptococcal virulence
Bisno, AL
Brito, MO
Collins, CM
[J]. LANCET INFECTIOUS DISEASES, 2003, 3 (04) : 191 - 200
[2] Group A Streptococcus tissue invasion by CD44-mediated cell signalling
Cywes, C
Wessels, MR
[J]. NATURE, 2001, 414 (6864) : 648 - 652
[3] Porphyromonas gingivalis traffics to autophagosomes in human coronary artery endothelial cells
Dorn, BR
Dunn, WA
Progulske-Fox, A
[J]. INFECTION AND IMMUNITY, 2001, 69 (09) : 5698 - 5708
[4] Interaction of the EEA1 FYVE finger with phosphatidylinositol 3-phosphate and early endosomes - Role of conserved residues
Gaullier, JM
Ronning, E
Gillooly, DJ
Stenmark, H
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (32) : 24595 - 24600
[5] LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
Kabeya, Y
Mizushima, N
Uero, T
Yamamoto, A
Kirisako, T
Noda, T
Kominami, E
Ohsumi, Y
Yoshimori, T
[J]. EMBO JOURNAL, 2000, 19 (21) : 5720 - 5728
[6] Cellular autophagy: Surrender, avoidance and subversion by microorganisms
Kirkegaard, K
Taylor, MP
Jackson, WT
[J]. NATURE REVIEWS MICROBIOLOGY, 2004, 2 (04) : 301 - 314
[7] Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells
Mizushima, N
Yamamoto, A
Hatano, M
Kobayashi, Y
Kabeya, Y
Suzuki, K
Tokuhisa, T
Ohsumi, Y
Yoshimori, T
[J]. JOURNAL OF CELL BIOLOGY, 2001, 152 (04) : 657 - 667
[8] Autophagosome formation in mammalian cells
Mizushima, N
Ohsumi, Y
Yoshimori, T
[J]. CELL STRUCTURE AND FUNCTION, 2002, 27 (06) : 421 - 429
[9] Two distinct pathways for the invasion of Streptococcus pyogenes in non-phagocytic cells
Molinari, G
Rohde, M
Guzmán, CA
Chhatwal, GS
[J]. CELLULAR MICROBIOLOGY, 2000, 2 (02) : 145 - 154
[10] Cytochrome c-mediated caspase-9 activation triggers apoptosis in Streptococcus pyogenes-infected epithelial cells
Nakagawa, I
Nakata, M
Kawabata, S
Hamada, S
[J]. CELLULAR MICROBIOLOGY, 2001, 3 (06) : 395 - 405

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