Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands

被引：74

作者：

Shah, N

Scanlan, TS ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Grad Grp Biophys, San Francisco, CA 94143 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 20期

关键词：

glucocorticoid; nuclear receptor; ligand;

D O I：

10.1016/j.bmcl.2004.07.052

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel class of phenylpyrazole fused Wieland-Miescher ketone derivatives are high affinity, receptor specific, selective modulators of glucocorticoid receptor (GR) mediated transcription in vitro, dissociating transactivation, AP-1 repression, and NF-kappaB repression from each other. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5199 / 5203

页数：5

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