Stereoselective synthesis of nitrogen-containing heterocycles via nickel-catalyzed cyclization of 1,3-diene and aldehyde:: Formal total synthesis of (-)-elaeokanine C

被引:49
作者
Sato, Y [1 ]
Saito, N [1 ]
Mori, M [1 ]
机构
[1] Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 060, Japan
关键词
D O I
10.1016/S0040-4020(97)10215-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Stereoselective syntheses of pyrrolidine, piperidine, pyrrolizidine and indolizidine skeletons were accomplished by nickel-catalyzed cyclization of 1,3-diene and aldehyde in a chain. A formal total synthesis of an Elaeocarpus alkaloid, (-)-Elaeokanine C, in the naturally occurring form was achieved using this cyclization. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1153 / 1168
页数:16
相关论文
共 34 条