Intimal thickness is not associated with wall shear stress patterns in the human right coronary artery

被引:67
作者
Joshi, AK
Leask, RL
Myers, JG
Ojha, M
Butany, J
Ethier, CR
机构
[1] Univ Toronto, Dept Mech & Ind Engn, Toronto, ON M5S 3G8, Canada
[2] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G8, Canada
[3] McGill Univ, Dept Chem Engn, Montreal, PQ, Canada
[4] NASA, John H Glenn Res Ctr, Brookpark, OH USA
[5] Univ Hlth Network, Dept Pathol, Toronto, ON, Canada
关键词
hemodynamics; intimal thickening; right coronary artery; wall shear stress; computational modeling;
D O I
10.1161/01.ATV.0000147118.97474.4b
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective - Low wall shear stress has been implicated in atherogenesis throughout the arterial tree, including the right coronary artery (RCA). The objective of this study was to determine the level of covariation of intimal thickness and wall shear stress in the human RCA. Methods and Results - Postmortem histological measurements of intimal thickness were compared with wall shear stresses calculated from computational flow modeling in 4 human right coronary arteries. A statistically significant correlation between intimal thickness and wall shear stress was found in only 1 of the 4 arteries studied. Conclusion - Wall shear stress does not appear to be related to intimal thickness in the 4 RCAs studied.
引用
收藏
页码:2408 / 2413
页数:6
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