Somatostatin suppresses ghrelin secretion from the rat stomach

被引：100

作者：

Shimada, M

Date, Y

Mondal, MS

Toshinai, K

Shimbara, T

Fukunaga, K

Murakami, N

Miyazato, M

Kangawa, K

Yoshimatsu, H

Matsuo, H

Nakazato, M ^{[1
]}

机构：

[1] Miyazaki Med Coll, Dept Internal Med, Miyazaki 8891692, Japan

[2] Oita Med Univ, Dept Internal Med, Oita 8795593, Japan

[3] Miyazaki Univ, Fac Agr, Dept Vet Physiol, Miyazaki 8892192, Japan

[4] Natl Cardiovasc Ctr, Inst Res, Dept Biochem, Osaka 5658565, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 302卷 / 03期

关键词：

ghrelin; somatostatin; vascular perfusion; immunohistochemistry;

D O I：

10.1016/S0006-291X(03)00178-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ghrelin is an acylated peptide that stimulates food intake and the secretion of growth hormone. While ghrelin is predominantly synthesized in a subset of endocrine cells in the oxyntic gland of the human and rat stomach, the mechanism regulating ghrelin secretion remains unknown. Somatostatin, a peptide produced in the gastric oxyntic mucosa, is known to suppress secretion of several gastrointestinal peptides in a paracrine fashion. By double immunohistochemistry, we demonstrated that somatostatin-immunoreactive cells contact ghrelin-immunoreactive cells. A single intravenous injection of somatostatin reduced the systemic plasma concentration of ghrelin in rats. Continuous infusion of somatostatin into the gastric artery of the vascularly perfused rat stomach, suppressed ghrelin secretion in both dose- and time-dependent manner. These findings indicate that ghrelin secretion from the stomach is regulated by gastric somatostatin. (C) 2003 Elsevier Science (USA). All rights reserved.

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页码：520 / 525

页数：6

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