The reductive coupling of tertiary amides to give enediamines using PhMe2SiLi

被引：19

作者：

Fleming, I

Ghosh, U

Mack, SR

Clark, BP

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Eli Lilly & Co, Lilly Res Ctr Ltd, Windlesham GU20 6PH, Surrey, England

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 06期

关键词：

D O I：

10.1039/a800648b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

PhMe2SiLi reacts with tertiary amides to give enediamines, which can be isolated in good yield when the alpha-carbon is branched; the enediamines can be hydrolysed more or less easily to alpha-amino ketones, isomerised from Z to E, oxidised to dienediamines and isomerised to amino enamines.

引用

收藏

页码：711 / 712

页数：2

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