mecA is not involved in the σB-dependent switch of the expression phenotype of methicillin resistance in Staphylococcus epidermidis

被引：19

作者：

Knobloch, JKM ^{[1
]}

Jäger, S ^{[1
]}

Huck, J ^{[1
]}

Horstkotte, MA ^{[1
]}

Mack, D ^{[1
]}

机构：

[1] Univ Klinikum Hamburg Eppendorf, Zentrum Klin Theoret Med, Inst Infekt Med, D-20246 Hamburg, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 03期

关键词：

D O I：

10.1128/AAC.49.3.1216-1219.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A lack of sigma(B) activity reduces methicillin resistance in heterogeneous Staphylococcus epidermidis 1057, whereas inactivation of the anti-sigma factor RsbW switched the phenotype to homogeneous expression of resistance. Oxacillin induction of mecA transcription is reduced in a sigma(B)-negative strain. However, mecA is not involved in the switch of expression phenotype.

引用

收藏

页码：1216 / 1219

页数：4

相关论文

共 23 条

[1] ANTIMICROBIAL SUSCEPTIBILITY OF COAGULASE-NEGATIVE STAPHYLOCOCCI [J].

ARCHER, GL ;

CLIMO, MW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (10) :2231-2237

[2] Methicillin resistance in staphylococci: Molecular and biochemical basis and clinical implications [J].

Chambers, HF .

CLINICAL MICROBIOLOGY REVIEWS, 1997, 10 (04) :781-+

[3] ADHERENCE OF SLIME-PRODUCING STRAINS OF STAPHYLOCOCCUS-EPIDERMIDIS TO SMOOTH SURFACES [J].

CHRISTENSEN, GD ;

SIMPSON, WA ;

BISNO, AL ;

BEACHEY, EH .

INFECTION AND IMMUNITY, 1982, 37 (01) :318-326

[4] PCR-based assay for discrimination between invasive and contaminating Staphylococcus epidermidis strains [J].

Frebourg, NB ;

Lefebvre, S ;

Baert, S ;

Lemeland, JF .

JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (02) :877-880

[5] Antimicrobial resistance prevalence rates in hospital antibiograms reflect prevalence rates among pathogens associated with hospital-acquired infections [J].

Fridkin, SK ;

Edwards, JR ;

Tenover, FC ;

Gaynes, RP ;

McGowan, JE .

CLINICAL INFECTIOUS DISEASES, 2001, 33 (03) :324-329

[6] RsbU-dependent regulation of Staphylococcus epidermidis biofilm formation is mediated via the alternative sigma factor σB by repression of the negative regulator gene icaR [J].

Knobloch, JKM ;

Jäger, S ;

Horstkotte, MA ;

Rohde, H ;

Mack, D .

INFECTION AND IMMUNITY, 2004, 72 (07) :3838-3848

[7] Evaluation of different detection methods of biofilm formation in Staphylococcus aureus [J].

Knobloch, JKM ;

Horstkotte, MA ;

Rohde, H ;

Mack, D .

MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 2002, 191 (02) :101-106

[8] Minimal attachment killing (MAK):: a versatile method for susceptibility testing of attached biofilm-positive and -negative Staphylococcus epidermidis [J].

Knobloch, JKM ;

von Osten, H ;

Horstkotte, MA ;

Rohde, H ;

Mack, D .

MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 2002, 191 (02) :107-114

[9] Alcoholic ingredients in skin disinfectants increase biofilm expression of Staphylococcus epidermidis [J].

Knobloch, JKM ;

Horstkotte, MA ;

Rohde, H ;

Kaulfers, PM ;

Mack, D .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2002, 49 (04) :683-687

[10] Biofilm formation by Staphylococcus epidermidis depends on functional RsbU, an activator of the sigB operon:: Differential activation mechanisms due to ethanol and salt stress [J].

Knobloch, JKM ;

Bartscht, K ;

Sabottke, A ;

Rohde, H ;

Feucht, HH ;

Mack, D .

JOURNAL OF BACTERIOLOGY, 2001, 183 (08) :2624-2633