A short synthesis of camptothecin via a 2-fluoro-1,4-dihydropyridine

被引：33

作者：

Bennasar, ML ^{[1
]}

Juan, C ^{[1
]}

Bosch, J ^{[1
]}

机构：

[1] Univ Barcelona, Fac Pharm, Organ Chem Lab, E-08028 Barcelona, Spain

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 24期

关键词：

D O I：

10.1039/b007814j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Addition of the enolate derived from isopropyl alpha-(methylsulfanyl)butyrate to N-(quinolylmethyl)-2-fluoro-pyridinium triflate 7, followed by oxidation-hydrolysis of the resultant 2-fluoro-1,4-dihydropyridine 8b afforded pyridone 9b, from which 20-deoxycamptothecin (11), a known precursor of camptothecin, was synthesized by a radical cyclization-desulfurization, with subsequent elaboration of the lactone E ring by chemoselective reduction.

引用

页码：2459 / 2460

页数：2

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