The promise of functional genomics: completing the encyclopedia of a cell

被引:37
作者
Hughes, TR
Robinson, MD
Mitsakakis, N
Johnston, M
机构
[1] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON M5G 1L6, Canada
[2] Washington Univ, Dept Genet, Sch Med, St Louis, MO 63110 USA
关键词
D O I
10.1016/j.mib.2004.08.015
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Genome sequencing provides complete parts lists of organisms. This presents the obvious challenge of determining how each gene contributes to the life of the organism. This task seems increasingly feasible; however, progress to date suggests that increased interaction between systematic efforts and individual investigators will be critical to completing the encyclopedia of the yeast cell.
引用
收藏
页码:546 / 554
页数:9
相关论文
共 53 条
[1]   The genome sequence of Drosophila melanogaster [J].
Adams, MD ;
Celniker, SE ;
Holt, RA ;
Evans, CA ;
Gocayne, JD ;
Amanatides, PG ;
Scherer, SE ;
Li, PW ;
Hoskins, RA ;
Galle, RF ;
George, RA ;
Lewis, SE ;
Richards, S ;
Ashburner, M ;
Henderson, SN ;
Sutton, GG ;
Wortman, JR ;
Yandell, MD ;
Zhang, Q ;
Chen, LX ;
Brandon, RC ;
Rogers, YHC ;
Blazej, RG ;
Champe, M ;
Pfeiffer, BD ;
Wan, KH ;
Doyle, C ;
Baxter, EG ;
Helt, G ;
Nelson, CR ;
Miklos, GLG ;
Abril, JF ;
Agbayani, A ;
An, HJ ;
Andrews-Pfannkoch, C ;
Baldwin, D ;
Ballew, RM ;
Basu, A ;
Baxendale, J ;
Bayraktaroglu, L ;
Beasley, EM ;
Beeson, KY ;
Benos, PV ;
Berman, BP ;
Bhandari, D ;
Bolshakov, S ;
Borkova, D ;
Botchan, MR ;
Bouck, J ;
Brokstein, P .
SCIENCE, 2000, 287 (5461) :2185-2195
[2]  
Alberts B., 2002, MOL BIOL CELL
[3]  
[Anonymous], 1998, SCIENCE, V282, P2012
[4]   Gene Ontology: tool for the unification of biology [J].
Ashburner, M ;
Ball, CA ;
Blake, JA ;
Botstein, D ;
Butler, H ;
Cherry, JM ;
Davis, AP ;
Dolinski, K ;
Dwight, SS ;
Eppig, JT ;
Harris, MA ;
Hill, DP ;
Issel-Tarver, L ;
Kasarskis, A ;
Lewis, S ;
Matese, JC ;
Richardson, JE ;
Ringwald, M ;
Rubin, GM ;
Sherlock, G .
NATURE GENETICS, 2000, 25 (01) :25-29
[5]   Functional genomics and proteomics: charting a multidimensional map of the yeast cell [J].
Bader, GD ;
Heilbut, A ;
Andrews, B ;
Tyers, M ;
Hughes, T ;
Boone, C .
TRENDS IN CELL BIOLOGY, 2003, 13 (07) :344-356
[6]  
Bateman A, 2004, NUCLEIC ACIDS RES, V32, pD138, DOI [10.1093/nar/gkp985, 10.1093/nar/gkr1065, 10.1093/nar/gkh121]
[7]   Ultraconserved elements in the human genome [J].
Bejerano, G ;
Pheasant, M ;
Makunin, I ;
Stephen, S ;
Kent, WJ ;
Mattick, JS ;
Haussler, D .
SCIENCE, 2004, 304 (5675) :1321-1325
[8]  
Broach JR., 1991, MOL CELLULAR BIOL YE
[9]   Topological structure analysis of the protein-protein interaction network in budding yeast [J].
Bu, DB ;
Zhao, Y ;
Cai, L ;
Xue, H ;
Zhu, XP ;
Lu, HC ;
Zhang, JF ;
Sun, SW ;
Ling, LJ ;
Zhang, N ;
Li, GJ ;
Chen, RS .
NUCLEIC ACIDS RESEARCH, 2003, 31 (09) :2443-2450
[10]   Yeast as a touchstone in post-genomic research: Strategies for integrative analysis in functional genomics [J].
Castrillo, JO ;
Oliver, SG .
JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2004, 37 (01) :93-106