Left ventricular assist device-induced reverse ventricular remodeling

被引：52

作者：

Burkhoff, D

Holmes, JW

Madigan, J

Barbone, A

Oz, MC

机构：

[1] Columbia Univ, Dept Med, New York, NY 10032 USA

[2] Columbia Univ, Dept Biomed Engn, New York, NY 10032 USA

[3] Columbia Univ, Dept Surg, New York, NY 10032 USA

来源：

PROGRESS IN CARDIOVASCULAR DISEASES | 2000年 / 43卷 / 01期

关键词：

D O I：

10.1053/pcad.2000.7190

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Left ventricular assist devices provide chronic pressure and volume unloading of the dilated left ventricle in patients with end-stage heart failure. This is associated with reverse structural remodeling (normalization of the passive pressure-volume relationship), reverse molecular remodeling (increased expression of several genes involved in calcium metabolism that are down-regulated in heart failure), improved baseline contractility, and improved contractile response to increased heart rate and to beta-agonist stimulation. These findings indicate the profound degree of recovery of myocardial properties in hearts previously considered to have invincible end- stage heart failure. Copyright (C) 2000 by W.B. Saunders Company.

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页码：19 / 26

页数：8

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