The thyroid hormone receptor β-specific agonist GC-1 selectively affects the bone development of hypothyroid rats

被引：46

作者：

Freitas, FRS

Capelo, LP

O'Shea, PJ

Jorgetti, V

Moriscot, AS

Scanlan, TS

Williams, GR

Zorn, TMT

Gouveia, CHA

机构：

[1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, BR-05508900 Sao Paulo, Brazil

[2] Univ Sao Paulo, Inst Biomed Sci, Dept Histol, BR-05508900 Sao Paulo, Brazil

[3] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Mol Endocrinol Grp, Div Med, London, England

[4] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Med Res Council Clin Sci Ctr, London, England

[5] Univ Sao Paulo, Sch Med, BR-05508900 Sao Paulo, Brazil

[6] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

[7] Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA 94143 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 02期

关键词：

thyroid receptors; bone development; growth plate chondrocytes; endochondral ossification; bone mass;

D O I：

10.1359/JBMR.041116

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We investigated the effects of GC-1, a TRbeta-selective thyromimetic, on bone development of hypothyroid rats. Whereas T3 reverted the IGF-I deficiency and the skeletal defects caused by hypothyroidism, GC-1 had no effect on serum IGF-I or on IGF-I protein expression in the epiphyseal growth plate of the femur, but induced selective effects on bone development. Our findings indicate that T3 exerts some essential effects on bone development that are mediated by TRbeta1.

引用

页码：294 / 304

页数：11

共 51 条

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