Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents

被引：102

作者：

de Vries, Anke ^{[1
]}

Custers, Erica ^{[2
]}

Lub, Johan ^{[2
]}

van den Bosch, Sandra ^{[2
]}

Nicolay, Klaas ^{[2
]}

Grull, Holger ^{[1
,2
]}

机构：

[1] Eindhoven Univ Technol, Dept Biomed Engn, Biomed NMR, NL-5600 MB Eindhoven, Netherlands

[2] Philips Res Eindhoven, Dept Biomol Engn, NL-5656 AE Eindhoven, Netherlands

来源：

BIOMATERIALS | 2010年 / 31卷 / 25期

关键词：

Computed tomography (CT); Contrast agent; Emulsion; Nanoparticles; Iodine; X-ray imaging; RAY COMPUTED-TOMOGRAPHY; BLOOD-POOL; NANOPARTICLES; GOLD; TOXICITY; MEDIA; RATS;

D O I：

10.1016/j.biomaterials.2010.04.056

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The objective of this study was to develop radiopaque iodinated emulsions for use as CT blood pool contrast agents. Three hydrophobic iodinated oils were synthesized based on the 2,3,5-triiodobenzoate moiety and formulated into emulsions using either phospholipids or amphiphilic polymers, i.e. Pluronic F68 and poly(butadiene)-b-poly(ethylene glycol) (PBD-PEO), as emulsifiers. The size, stability and cell viability was investigated for all stabilized emulsions. Three emulsions stabilized with either lipids or PBD-PEO were subsequently tested in vivo as a CT blood pool contrast agent in mice. While the lipid-stabilized emulsions turned out unstable in vivo, polymer-stabilized emulsions performed well in vivo. In blood, a contrast enhancement of 220 Hounsfield Units (HU) was measured directly after intravenous administration of 520 mg l/kg. The blood circulation half-life of a PBD-PEO stabilized emulsion was approximately 3 h and no noticeable in vivo toxicity was observed. These results show the potential of above emulsions for use as blood pool agents in contrast enhanced CT imaging. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6537 / 6544

页数：8

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