Multicopy blaOXA-58 gene as a source of high-Level resistance to carbapenems in Acinetobacter baumannii

被引：93

作者：

Bertini, Alessia

Poirel, Laurent

Bernabeu, Sandrine

Fortini, Daniela

Villa, Laura

Nordmann, Patrice

Carattoli, Alessandra

机构：

[1] Ist Super Sanita, Dept Infect Parasit Immunemediated Dis, I-00161 Rome, Italy

[2] Univ Paris 11, Hop Bicetre, Serv Bacteriol Virol, Le Kremlin Bicetre, France

[3] Univ Paris 11, Assistance Publ Hop Paris, Serv Bacteriol Virol, Le Kremlin Bicetre, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 07期

关键词：

D O I：

10.1128/AAC.01502-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The mechanisms at the origin of heterogeneous carbapenem resistance levels observed among Acinetobacter baumannii isolates collected in 2005 in a large University Hospital of Rome, Italy, were investigated. These isolates were related and possessed similar plasmids carrying the carbapenem-hydrolyzing oxacillinase gene bla(OXA-58) but showed variable levels of resistance to carbapenems. Analysis of sequences surrounding the bla(OXA-58) gene showed genetic variability, with the presence in several isolates of multiple copies of the bla(OXA-58) gene; this extra copy number was likely related to an IS26-mediated transposition or recombination process.

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页码：2324 / 2328

页数：5

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