Dysregulated MicroRNA involvement in Multiple Sclerosis by induction of T Helper 17 Cell Differentiation

被引：53

作者：

Chen, Chen ^{[1
]}

Zhou, Yifan ^{[1
]}

Wang, Jingqi ^{[1
]}

Yan, Yaping ^{[1
,2
]}

Peng, Lisheng ^{[1
]}

Qiu, Wei ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Neurol, Guangzhou, Guangdong, Peoples R China

[2] Shaanxi Normal Univ, Coll Life Sci, Natl Engn Lab Resource Dev Endangered Crude Drugs, Key Lab,Minist Educ Med Resources & Nat Pharmaceu, Xian, Shaanxi, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷

基金：

中国国家自然科学基金;

关键词：

microRNA; T helper 17 cells; multiple sclerosis; treatment; experimental autoimmune encephalomyelitis; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; SUPPRESSES TH17 DIFFERENTIATION; CENTRAL-NERVOUS-SYSTEM; CIRCULATING MICRORNAS; DOWN-REGULATION; EXPRESSION; INFLAMMATION; PATHOGENESIS; BLOOD; FINGOLIMOD;

D O I：

10.3389/fimmu.2018.01256

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system. Growing evidence has proven that T helper 17 (Th17) cells are one of the regulators of neuroinflammation mechanisms in MS disease. Researchers have demonstrated that some microRNAs (miRNAs) are associated with disease activity and duration, even with different MS patterns. miRNAs regulate CD4(+) T cells to differentiate toward various T cell subtypes including Th17 cells. In this review, we discuss the possible mechanisms of miRNAs in MS pathophysiology by regulating CD4(+) T cell differentiation into Th17 cells, and potential miRNA targets for current disease-modifying treatments.

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页数：10

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