Synthesis of the human aldose reductase inhibitor rubrolide L

被引：46

作者：

Boukouvalas, John ^{[1
]}

McCann, Lucas C. ^{[1
]}

机构：

[1] Univ Laval, Dept Chim, Quebec City, PQ G1V 0A6, Canada

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 35期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Diabetes; Selective bromination; Suzuki-Miyaura cross-coupling; Vinylogous aldol condensation; EFFICIENT TOTAL-SYNTHESIS; CROSS-COUPLING REACTIONS; SUBSTITUTED BUTENOLIDES; SELECTIVE SYNTHESIS; NATURAL-PRODUCTS; FACILE SYNTHESIS; ACID; ARYL; ACCESS; STEREOCHEMISTRY;

D O I：

10.1016/j.tetlet.2010.06.129

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first synthesis of rubrolide L, a marine ascidian butenolide and a potent inhibitor of human aldose reductase, has been achieved by two tactically distinct pathways in 4-5 steps and 37-42% overall yield from commercially available 3-chlorotetronic acid. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4636 / 4639

页数：4

共 63 条

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