Anti-inflammatory activity of Dalbergia lanceolaria bark ethanol extract in mice and rats

被引：39

作者：

Kale, Mrudula ^{[1
]}

Misar, A. V. ^{[1
]}

Dave, Vivek ^{[1
]}

Joshi, Maruti ^{[1
]}

Mujumdar, A. M. ^{[1
]}

机构：

[1] Agharkar Res Inst, Plant Sci Div, Pune 411004, Maharashtra, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2007年 / 112卷 / 02期

关键词：

Dalbergia lanceolaria L; albino rats; albino mice; topical and systemic anti-inflammatory activity;

D O I：

10.1016/j.jep.2007.03.024

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Topical anti-inflammatory activity of Dalbergia lanceolaria Linn. bark ethanol extract was demonstrated in albino mice using TPA-, EPP- and AA-induced ear edema models. The systemic activity of extract was confirmed using acuteand sub-acute anti-inflammatory models in albino rats. The ethanol extract exhibited significant systemic anti -inflammatory activity in Carrageenan-induced rat paw edema, by inhibition of histamine and prostaglandin phases of acute inflammation. The extract also showed significant activity against turpentine-induced exudative changes and no activity against granular tissue formation in cotton pellet-induced granuloma in albino rats. Thus, resultant anti-inflammatory activity might be due to effects on several mediators involving cyclo-oxygenase pathway resulting in prostaglandin formation and leukocyte migration from the vessels. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：300 / 304

页数：5

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