Capillary electrophoretic analysis of ethylene dicysteine, a precursor of the radiopharmaceutical Tc-99m ethylene dicysteine

被引：6

作者：

VanSchepdael, A ^{[1
]}

Verbeke, K ^{[1
]}

VanNerom, C ^{[1
]}

Hoogmartens, J ^{[1
]}

Verbruggen, A ^{[1
]}

机构：

[1] UNIV CATHOLIQUE LOUVAIN, FAC FARMACEUT WETENSCHAPPEN, UZ LEUVEN, LAB RADIOFARMACEUT CHEM, B-3000 LOUVAIN LA NEUVE, BELGIUM

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 1997年 / 697卷 / 1-2期

关键词：

ethylene dicysteine;

D O I：

10.1016/S0378-4347(97)00027-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

L,L-Ethylene dicysteine (EC) is a ligand used in nuclear medicine for the preparation of Tc-99m-L,L-EC, a tracer agent for renal function studies. A capillary zone electrophoretic method is described which allows us to monitor the purity of ethylene dicysteine, for which no other suitable method has been reported to date. A fused-silica capillary (L=70 cm, l=62 cm, 75 mu m I.D.) was used with 10 mM sodium tetraborate, pK 10.0, as the background electrolyte. The voltage applied was 20 kV and the temperature was 25 degrees C. Benzyl alcohol served as the internal standard. The limit of detection was 0.07% and the limit of quantitation was 0.15%. (C) 1997 Elsevier Science B.V.

引用

页码：251 / 254

页数：4

共 5 条

[1] DIMERIZATION OF AN INTERMEDIATE DURING SODIUM IN LIQUID AMMONIA REDUCTION OF L-THIAZOLIDINE-4-CARBOXYLIC ACID [J].