Simultaneous multicolor imaging of five different lymphatic basins using quantum dots

被引：264

作者：

Kobayashi, Hisataka

Hama, Yukihiro

Koyama, Yoshinori

Barrett, Tristan

Regino, Celeste A. S.

Urano, Yasuteru

Choyke, Peter L.

机构：

[1] NCI, Mol Imaging Program, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[2] NCI, Radiat Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA

[3] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

NANO LETTERS | 2007年 / 7卷 / 06期

关键词：

D O I：

10.1021/nl0707003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Quantum dots can be used to perform multicolor images with high fluorescent intensity and are of a nanosize suitable for lymphatic imaging via direct interstitial injection. Here simultaneous multicolor in vivo wavelength-resolved spectral fluorescence lymphangiography is shown using five quantum dots with similar physical sizes but different emission spectra. This allows noninvasive and simultaneous visualization of five separate lymphatic flows draining and may have implications for predicting the route of cancer metastasis into the lymph nodes.

引用

收藏

页码：1711 / 1716

页数：6

相关论文

共 13 条

[1] Model to quantify lymph node enhancement on indirect sonographic lymphography [J].

Choi, SH ;

Kono, Y ;

Corbeil, J ;

Lucidarme, O ;

Mattrey, RF .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2004, 183 (02) :513-517

[2] In vivo cancer targeting and imaging with semiconductor quantum dots [J].

Gao, XH ;

Cui, YY ;

Levenson, RM ;

Chung, LWK ;

Nie, SM .

NATURE BIOTECHNOLOGY, 2004, 22 (08) :969-976

[3] Multiplexed toxin analysis using four colors of quantum dot fluororeagents [J].

Goldman, ER ;

Clapp, AR ;

Anderson, GP ;

Uyeda, HT ;

Mauro, JM ;

Medintz, IL ;

Mattoussi, H .

ANALYTICAL CHEMISTRY, 2004, 76 (03) :684-688

[4]

HAMA Y, 2007, IN PRESS J INVEST DE

[5] Simultaneous two-color spectral fluorescence lymphangiography with near infrared quantum dots to map two lymphatic flows from the breast and the upper extremity [J].

Hama, Yukihiro ;

Koyama, Yoshinori ;

Urano, Yasuteru ;

Choyke, Peter L. ;

Kobayashi, Hisataka .

BREAST CANCER RESEARCH AND TREATMENT, 2007, 103 (01) :23-28

[6] A toxicologic review of quantum dots: Toxicity depends on physicochemical and environmental factors [J].

Hardman, R .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2006, 114 (02) :165-172

[7] The multiple uses of fluorescent proteins to visualize cancer in vivo [J].

Hoffman, RM .

NATURE REVIEWS CANCER, 2005, 5 (10) :796-806

[8] Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping [J].

Kim, S ;

Lim, YT ;

Soltesz, EG ;

De Grand, AM ;

Lee, J ;

Nakayama, A ;

Parker, JA ;

Mihaljevic, T ;

Laurence, RG ;

Dor, DM ;

Cohn, LH ;

Bawendi, MG ;

Frangioni, JV .

NATURE BIOTECHNOLOGY, 2004, 22 (01) :93-97

[9] Delivery of gadolinium-labeled nanoparticles to the sentinel lymph node: Comparison of the sentinel node visualization and estimations of intra-nodal gadolinium concentration by the magnetic resonance imaging [J].

Kobayashi, H ;

Kawamoto, S ;

Bernardo, M ;

Brechbiel, MW ;

Knopp, MV ;

Choyke, PL .

JOURNAL OF CONTROLLED RELEASE, 2006, 111 (03) :343-351

[10] Comparison of dendrimer-based macromolecular contrast agents for dynamic micro-magnetic resonance lymphangiography [J].

Kobayashi, H ;

Kawamoto, S ;

Choyke, PL ;

Sato, N ;

Knopp, MV ;

Star, RA ;

Waldmann, TA ;

Tagaya, Y ;

Brechbiel, MW .

MAGNETIC RESONANCE IN MEDICINE, 2003, 50 (04) :758-766