Variation in gene expression patterns in follicular lymphoma and the response to rituximab

被引：112

作者：

Bohen, SP

Troyanskaya, OG

Alter, O

Warnke, R

Botstein, D ^{[1
]}

Brown, PO

Levy, R

机构：

[1] Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

[4] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

[5] Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 04期

关键词：

D O I：

10.1073/pnas.0437875100

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Analysis of the patterns of gene expression in follicular lymphomas from 24 patients suggested that two groups of tumors might be distinguished. All patients, whose biopsies were obtained before any treatment, were treated with rituximab, a monoclonal antibody directed against the B cell antigen, CD20. Gene expression patterns in the tumors that subsequently failed to respond to rituximab appeared more similar to those of normal lymphoid tissues than to gene expression patterns of tumors from rituximab responders. These findings suggest the possibility that the response of follicular lymphoma to rituximab treatment may be predicted from the gene expression pattern of tumors.

引用

页码：1926 / 1930

页数：5

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