The Virologic and Immunologic Effects of Cyclosporine as an Adjunct to Antiretroviral Therapy in Patients Treated during Acute and Early HIV-1 Infection

被引：27

作者：

Markowitz, Martin ^{[1
]}

Vaida, Florin ^{[4
,5
]}

Hare, C. Bradley ^{[4
]}

Boden, Daniel ^{[1
]}

Mohri, Hiroshi ^{[1
]}

Hecht, Frederick M. ^{[4
]}

Kalayjian, Robert C. ^{[7
]}

Conrad, Ann ^{[7
]}

Mildvan, Donna ^{[2
]}

Aberg, Judith ^{[3
]}

Hogan, Christine ^{[1
]}

Kilby, J. Michael ^{[8
]}

Balfour, Henry H., Jr. ^{[9
]}

Schafer, Kim ^{[4
,5
]}

Richman, Douglas ^{[4
,5
,6
]}

Little, Susan ^{[4
,5
]}

机构：

[1] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

[2] Beth Israel Deaconess Med Ctr, Dept Med, Div Infect Dis, New York, NY 10003 USA

[3] NYU, Sch Med, Dept Med, Div Infect Dis, New York, NY USA

[4] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA

[5] Univ Calif San Diego, Dept Pathol, San Diego, CA 92103 USA

[6] Vet Adm San Diego Healthcare Syst, San Diego, CA USA

[7] Metrohlth Med Ctr, Dept Med, Cleveland, OH USA

[8] Univ Alabama, Dept Med, Birmingham, AL 35294 USA

[9] Univ Minnesota, Minneapolis, MN USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 201卷 / 09期

基金：

美国国家卫生研究院;

关键词：

CD4(+) T-LYMPHOCYTES; GASTROINTESTINAL-TRACT; DEPLETION;

D O I：

10.1086/651664

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Acute human immunodeficiency virus type 1 (HIV-1) infection is characterized by high levels of immune activation. Immunomodulation with cyclosporine combined with antiretroviral therapy (ART) in the setting of acute and early HIV-1 infection has been reported to result in enhanced immune reconstitution. Fifty-four individuals with acute and early infection were randomized to receive ART with 4 weeks of cyclosporine versus ART alone. In 48 subjects who completed the study, there were no significant differences between treatment arms in levels of proviral DNA or CD4(+) T cell counts. Adjunctive therapy with cyclosporine in this setting does not provide apparent virologic or immunologic benefit.

引用

页码：1298 / 1302

页数：5

共 15 条

[1] CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract [J].

Brenchley, JM ;

Schacker, TW ;

Ruff, LE ;

Price, DA ;

Taylor, JH ;

Beilman, GJ ;

Nguyen, PL ;

Khoruts, A ;

Larson, M ;

Haase, AT ;

Douek, DC .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (06) :749-759

[2] HIV preferentially infects HIV-specific CD4+ T cells [J].

Douek, DC ;

Brenchley, JM ;

Betts, MR ;

Ambrozak, DR ;

Hill, BJ ;

Okamoto, Y ;

Casazza, JP ;

Kuruppu, J ;

Kuntsman, K ;

Wolinsky, S ;

Grossman, Z ;

Dybul, M ;

Oxenius, A ;

Price, DA ;

Connors, M ;

Koup, RA .

NATURE, 2002, 417 (6884) :95-98

[3] CYCLOSPORINE-A SPECIFICALLY INHIBITS FUNCTION OF NUCLEAR PROTEINS INVOLVED IN T-CELL ACTIVATION [J].

EMMEL, EA ;

VERWEIJ, CL ;

DURAND, DB ;

HIGGINS, KM ;

LACY, E ;

CRABTREE, GR .

SCIENCE, 1989, 246 (4937) :1617-1620

[4] THE OPTIMAL USE OF CYCLOSPORINE-A IN AUTOIMMUNE-DISEASES [J].

FEUTREN, G .

JOURNAL OF AUTOIMMUNITY, 1992, 5 :183-195

[5] A multicenter observational study of the potential benefits of initiating combination antiretroviral therapy during acute HIV infection [J].

Hecht, Frederick M. ;

Wang, Lei ;

Collier, Ann ;

Little, Susan ;

Markowitz, Martin ;

Margolick, Joseph ;

Kilby, J. Michael ;

Daar, Eric ;

Conway, Brian ;

Holte, Sarah .

JOURNAL OF INFECTIOUS DISEASES, 2006, 194 (06) :725-733

[6] Predictors of virological outcome and safety in primary HIV type 1-infected patients initiating quadruple antiretroviral therapy: QUEST GW PROB3005 [J].

Hoen, Bruno ;

Cooper, David A. ;

Lampe, Fiona C. ;

Perrin, Luc ;

Clumeck, Nathan ;

Phillips, Andrew N. ;

Goh, Li-Ean ;

Lindback, Stefan ;

Sereni, Daniel ;

Gazzard, Brian ;

Montaner, Julio ;

Stellbrink, Hans-Jurgen ;

Lazzarin, Adriano ;

Ponscarme, Diane ;

Staszewski, Shlomo ;

Mathiesen, Lars ;

Smith, Don ;

Finlayson, Robert ;

Weber, Rainer ;

Wegmann, Laurence ;

Janossy, George ;

Kinloch-de Loes, Sabine .

CLINICAL INFECTIOUS DISEASES, 2007, 45 (03) :381-390

[7] The effect of commencing combination antiretroviral therapy soon after human immunodeficiency virus type 1 infection on viral replication and antiviral immune responses [J].

Markowitz, M ;

Vesanen, M ;

Tenner-Racz, K ;

Cao, YZ ;

Binley, JM ;

Talal, A ;

Hurley, A ;

Ji, X ;

Chaudhry, MR ;

Yaman, M ;

Frankel, S ;

Heath-Chiozzi, M ;

Leonard, JM ;

Moore, JP ;

Racz, P ;

Nixon, DF ;

Ho, DD .

JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (03) :527-537

[8] Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract [J].

Mehandru, S ;

Poles, MA ;

Tenner-Racz, K ;

Horowitz, A ;

Hurley, A ;

Hogan, C ;

Boden, D ;

Racz, P ;

Markowitz, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (06) :761-770

[9] Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection [J].

Mehandru, Saurabh ;

Poles, Michael A. ;

Tenner-Racz, Klara ;

Jean-Pierre, Patrick ;

Manuelli, Victoria ;

Lopez, Peter ;

Shet, Anita ;

Low, Andrea ;

Mohri, Hiroshi ;

Boden, Daniel ;

Racz, Paul ;

Markowitz, Martin .

PLOS MEDICINE, 2006, 3 (12) :2335-2348

[10]

MIRO J, 2009, 16 C RETR OPP INF MO

← 1 2 →