Endothelial adherens junctions

被引:27
作者
Petzelbauer, P [1 ]
Halama, T [1 ]
Gröger, M [1 ]
机构
[1] Univ Vienna, Sch Med, Dept Dermatol, Div Gen Dermatol, A-1090 Vienna, Austria
关键词
angiogenesis; beta-catenin; inflammation; PECAM-1; VE-cadherin;
D O I
10.1046/j.1087-0024.2000.00002.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The principle of the molecular organization of adherens junctions follows a uniform pattern, which is found in epithelial, muscular, neuroneal as well as in endothelial cells and is highly conserved among species. Transmembrane molecules of the cadherin family link to catenins, which anchor the adhesion plaque to the cytoskeleton. The kind of cadherin used in adherens junctions is cell-type specific, vascular endothelial (VE)-cadherin is specific for endothelial cells. The assembly and disassembly of the cadherin/catenin complex is dynamic and regulated by growth factors. The functional status of adherens junctions controls endothelial cell-to-cell adhesion, cell scattering, vessel morphogenesis and has intracellular signaling properties, thereby playing an important role in vasculogenesis and angiogenesis.
引用
收藏
页码:10 / 13
页数:4
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