Compartmentalization of prokaryotic DNA replication

被引：20

作者：

Bravo, A ^{[1
]}

Serrano-Heras, G ^{[1
]}

Salas, M ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Inst Biol Mol Eladio Vinuela, Ctr Biol Mol Severo Ochoa, CSIC,UAM, E-28049 Madrid, Spain

来源：

FEMS MICROBIOLOGY REVIEWS | 2005年 / 29卷 / 01期

关键词：

DNA replication; fluorescence microscopy; membrane; prokaryotes;

D O I：

10.1016/j.femsre.2004.06.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

It becomes now apparent that prokaryotic DNA replication takes place at specific intracellular locations. Early studies indicated that chromosomal DNA replication, as well as plasmid and viral DNA replication, occurs in close association with the bacterial membrane. Moreover, over the last several years, it has been shown that some replication proteins and specific DNA sequences are localized to particular subcellular regions in bacteria, supporting the existence of replication compartments. Although the mechanisms underlying compartmentalization of prokaryotic DNA replication are largely unknown, the docking of replication factors to large organizing structures may be important for the assembly of active replication complexes. In this article, we review the current state of this subject in two bacterial species, Escherichia coli and Bacillus subtilis, focusing our attention in both chromosomal and extrachromosomal DNA replication. A comparison with eukaryotic systems is also presented. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：25 / 47

页数：23

共 228 条

[1] Semliki Forest virus mRNA capping enzyme requires association with anionic membrane phospholipids for activity [J].