Determination of amphetamine-derived designer drugs in human urine by SPE extraction and capillary electrophoresis with mass spectrometry detection

被引：56

作者：

Boatto, G ^{[1
]}

Nieddu, M ^{[1
]}

Carta, A ^{[1
]}

Pau, A ^{[1
]}

Palomba, M ^{[1
]}

Asproni, B ^{[1
]}

Cerri, R ^{[1
]}

机构：

[1] Univ Sassari, Dipartimento Farm Chim Tossicol, I-07100 Sassari, Italy

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2005年 / 814卷 / 01期

关键词：

methylenedioxy-derivates; amphetamine; phenylethylamine; designer drug; urine; capillary electrophoresis; mass spectrometry; solid-phase extraction (SPE);

D O I：

10.1016/j.jchromb.2004.10.010

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, a number of newer designer drugs have entered the illicit drug market. The methylenedioxy-derivates of amphetamine represent the largest group of designer drugs. This paper describes a method for screening for and quantification of ten 2,5-methylenedioxy-derivates of amphetamine and phenylethylamine in human urine, using capillary electrophoresis coupled to electrospray ionisation-mass spectrometry (CE-ESI-MS). Prior to CE-MS analysis, a simple solid-phase extraction (SPE) was used for sample cleanup. The method was validates according to international guidelines. (C) 2004 Elsevier B.V. All rights reserved.

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页码：93 / 98

页数：6

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