Noncoding RNA Gas5 Is a Growth Arrest- and Starvation-Associated Repressor of the Glucocorticoid Receptor

被引：951

作者：

Kino, Tomoshige ^{[1
]}

Hurt, Darrell E. ^{[2
]}

Ichijo, Takamasa ^{[1
]}

Nader, Nancy ^{[1
]}

Chrousos, George P. ^{[3
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Unit Mol Hormone Act, Program Reprod & Adult Endocrinol, NIH,Clin Res Ctr, Bethesda, MD 20892 USA

[2] NIAID, Bioinformat & Sci IT Program, NIH, Bethesda, MD 20892 USA

[3] Univ Athens, Sch Med, Dept Pediat 1, GR-11527 Athens, Greece

来源：

SCIENCE SIGNALING | 2010年 / 3卷 / 107期

关键词：

NECROSIS-FACTOR-ALPHA; GENE-EXPRESSION; TRANSCRIPTIONAL ACTIVITY; CLINICAL-IMPLICATIONS; CELLULAR INHIBITOR; INDUCED APOPTOSIS; DNA-BINDING; PROTEIN; CELLS; DEXAMETHASONE;

D O I：

10.1126/scisignal.2000568

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The availability of nutrients influences cellular growth and survival by affecting gene transcription. Glucocorticoids also influence gene transcription and have diverse activities on cell growth, energy expenditure, and survival. We found that the growth arrest-specific 5 (Gas5) noncoding RNA, which is abundant in cells whose growth has been arrested because of lack of nutrients or growth factors, sensitized cells to apoptosis by suppressing glucocorticoid-mediated induction of several responsive genes, including the one encoding cellular inhibitor of apoptosis 2. Gas5 bound to the DNA-binding domain of the glucocorticoid receptor (GR) by acting as a decoy glucocorticoid response element (GRE), thus competing with DNA GREs for binding to the GR. We conclude that Gas5 is a "riborepressor" of the GR, influencing cell survival and metabolic activities during starvation by modulating the transcriptional activity of the GR.

引用

页数：15

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