Chemotactic signaling pathways in neutrophils: From receptor to actin assembly

被引：86

作者：

Cicchetti, G ^{[1
]}

Allen, PG ^{[1
]}

Glogauer, M ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Hematol Div,LMRC 301, Boston, MA 02115 USA

来源：

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE | 2002年 / 13卷 / 03期

关键词：

neutrophil; chemotaxis; actin; cytoskeleton;

D O I：

10.1177/154411130201300302

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

In this review, we present an overview of the signaling elements between neutrophil chemotactic receptors and the actin cytoskeleton that drives cell motility. From receptor-ligand interactions, activation of heterotrimeric G-proteins, their downstream effectors PLC and PI-3 kinase, the activation of small GTPases of the Rho family, and their regulation of particular cytoskeletal regulatory proteins, we describe pathways specific to the chemotaxing neutrophil and elements documented to be important for neutrophil function.

引用

页码：220 / 228

页数：9

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