Chemotactic signaling pathways in neutrophils: From receptor to actin assembly

被引：86

作者：

Cicchetti, G ^{[1
]}

Allen, PG ^{[1
]}

Glogauer, M ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Hematol Div,LMRC 301, Boston, MA 02115 USA

来源：

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE | 2002年 / 13卷 / 03期

关键词：

neutrophil; chemotaxis; actin; cytoskeleton;

D O I：

10.1177/154411130201300302

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

In this review, we present an overview of the signaling elements between neutrophil chemotactic receptors and the actin cytoskeleton that drives cell motility. From receptor-ligand interactions, activation of heterotrimeric G-proteins, their downstream effectors PLC and PI-3 kinase, the activation of small GTPases of the Rho family, and their regulation of particular cytoskeletal regulatory proteins, we describe pathways specific to the chemotaxing neutrophil and elements documented to be important for neutrophil function.

引用

页码：220 / 228

页数：9

共 105 条

[61]

PARK DG, 1993, J BIOL CHEM, V268, P4573

[62] Activation of human neutrophils by Mycobacterium tuberculosis H37Ra involves phospholipase Cγ2, Shc adapter protein, and p38 mitogen-activated protein kinase [J].

Perskvist, N ;

Zheng, LM ;

Stendahl, O .

JOURNAL OF IMMUNOLOGY, 2000, 164 (02) :959-965

[63] Molecular mechanisms controlling actin filament dynamics in nonmuscle cells [J].

Pollard, TD ;

Blanchoin, L ;

Mullins, RD .

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 2000, 29 :545-576

[64] The modular structure of actin-regulatory proteins [J].

Puius, YA ;

Mahoney, NM ;

Almo, SC .

CURRENT OPINION IN CELL BIOLOGY, 1998, 10 (01) :23-34

[65] GUANINE-NUCLEOTIDE EXCHANGE FACTORS - ACTIVATORS OF THE RAS SUPERFAMILY OF PROTEINS [J].

QUILLIAM, LA ;

KHOSRAVIFAR, R ;

HUFF, SY ;

DER, CJ .

BIOESSAYS, 1995, 17 (05) :395-404

[66] The role of phosphoinositide 3-kinase lipid products in cell function [J].

Rameh, LE ;

Cantley, LC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (13) :8347-8350

[67] ACTIVATION OF HUMAN NEUTROPHIL PHOSPHOLIPASE-D BY 3 SEPARABLE MECHANISMS [J].

REINHOLD, SL ;

PRESCOTT, SM ;

ZIMMERMAN, GA ;

MCINTYRE, TM .

FASEB JOURNAL, 1990, 4 (02) :208-214

[68] Regulation of phosphoinositide-specific phospholipase C [J].

Rhee, SG .

ANNUAL REVIEW OF BIOCHEMISTRY, 2001, 70 :281-312

[69] Leukocytes navigate by compass:: roles of PI3Kγ and its lipid products [J].

Rickert, P ;

Weiner, OD ;

Wang, F ;

Bourne, HR ;

Servant, G .

TRENDS IN CELL BIOLOGY, 2000, 10 (11) :466-473

[70] THE SMALL GTP-BINDING PROTEIN RAC REGULATES GROWTH-FACTOR INDUCED MEMBRANE RUFFLING [J].

RIDLEY, AJ ;

PATERSON, HF ;

JOHNSTON, CL ;

DIEKMANN, D ;

HALL, A .

CELL, 1992, 70 (03) :401-410

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