Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia

被引:36
作者
Su, XY
Busson, M
Della Valle, V
Ballerini, P
Dastugue, N
Talmant, P
Ferrando, AA
Baudry-Bluteau, D
Romana, S
Berger, R
Bernard, OA
机构
[1] Hop Necker Enfants Malad, INSERM EMI 0210, IRNEM, F-75015 Paris, France
[2] Hop Enfants Armand Trousseau, Serv Hematol BIol, Paris, France
[3] Hop Purpan, Hematol Lab, Toulouse, France
[4] Hop Hotel Dieu, Lab Cytogenet, Nantes, France
[5] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
[6] Harvard Univ, Sch Med, Boston, MA USA
关键词
D O I
10.1002/gcc.20088
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Most chromosomal translocations observed in T-cell acute lymphoblastic leukemia (T-ALL) often produce transcriptional activation of transcription factor oncogenes. Ectopic expression of the TLX3 (also known as HOXIIL2) gene has been shown to be associated with a cryptic t(5; 14)(q35;q32) translocation specific for a subtype of T-ALL. Here we report several examples of variant and alternative translocations resulting in expression of TLX3 in T-ALL, and we describe three of these translocations in detail. In particular, the CDK6 gene was rearranged in two t(5;7)(q35;q21) translocations. In two additional instances, fusion of the BCLIIB (also known as CTIP2) and RANBP17/TLX3 loci were shown to result from subtle genomic insertion/deletion within these loci. This study further underscores that TLX3 expression in T-ALL is strongly associated with the presence of genomic rearrangements. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码:243 / 249
页数:7
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