Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia

被引：36

作者：

Su, XY

Busson, M

Della Valle, V

Ballerini, P

Dastugue, N

Talmant, P

Ferrando, AA

Baudry-Bluteau, D

Romana, S

Berger, R

Bernard, OA

机构：

[1] Hop Necker Enfants Malad, INSERM EMI 0210, IRNEM, F-75015 Paris, France

[2] Hop Enfants Armand Trousseau, Serv Hematol BIol, Paris, France

[3] Hop Purpan, Hematol Lab, Toulouse, France

[4] Hop Hotel Dieu, Lab Cytogenet, Nantes, France

[5] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Boston, MA USA

来源：

GENES CHROMOSOMES & CANCER | 2004年 / 41卷 / 03期

关键词：

D O I：

10.1002/gcc.20088

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Most chromosomal translocations observed in T-cell acute lymphoblastic leukemia (T-ALL) often produce transcriptional activation of transcription factor oncogenes. Ectopic expression of the TLX3 (also known as HOXIIL2) gene has been shown to be associated with a cryptic t(5; 14)(q35;q32) translocation specific for a subtype of T-ALL. Here we report several examples of variant and alternative translocations resulting in expression of TLX3 in T-ALL, and we describe three of these translocations in detail. In particular, the CDK6 gene was rearranged in two t(5;7)(q35;q21) translocations. In two additional instances, fusion of the BCLIIB (also known as CTIP2) and RANBP17/TLX3 loci were shown to result from subtle genomic insertion/deletion within these loci. This study further underscores that TLX3 expression in T-ALL is strongly associated with the presence of genomic rearrangements. (C) 2004 Wiley-Liss, Inc.

引用

页码：243 / 249

页数：7

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