An evolutionary and structural perspective on T cell antigen receptor function

被引:44
作者
Malissen, B [1 ]
机构
[1] Ctr Immunol, INSERM CNRS Marseille Luminy, F-13288 Marseille 9, France
关键词
D O I
10.1034/j.1600-065X.2003.00016.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
After a brief overview of the themes and variations that occur in the family of receptors containing immunoreceptor tyrosine-based activation motifs (ITAMs), and of recent structural data on the ligand-binding subunits of these receptors, we use these data to revisit how information on the state and quality of occupancy of the binding site of the T cell antigen receptor (TCR) is conveyed to the proximal components of the TCR transduction cassette.
引用
收藏
页码:7 / 27
页数:21
相关论文
共 123 条
[1]   Interplays between mouse mammary tumor virus and the cellular and humoral immune response [J].
Acha-Orbea, H ;
Finke, D ;
Attinger, A ;
Schmid, S ;
Wehrli, N ;
Vacheron, S ;
Xenarios, I ;
Scarpellino, L ;
Toellner, KM ;
MacLennan, ICM ;
Luther, SA .
IMMUNOLOGICAL REVIEWS, 1999, 168 :287-303
[2]   Induction of T helper type 2 immunity by a point mutation in the LAT adaptor [J].
Aguado, E ;
Richelme, S ;
Nuñez-Cruz, S ;
Miazek, A ;
Mura, AM ;
Richelme, M ;
Guo, XJ ;
Sainty, D ;
He, HT ;
Malissen, B ;
Malissen, M .
SCIENCE, 2002, 296 (5575) :2036-2040
[3]  
Aivazian D, 2000, NAT STRUCT BIOL, V7, P1023
[4]   Structure of a human γδ T-cell antigen receptor [J].
Allison, TJ ;
Winter, CC ;
Fournié, JJ ;
Bonneville, M ;
Garboczi, DN .
NATURE, 2001, 411 (6839) :820-824
[5]   CYTOPLASMIC DOMAIN HETEROGENEITY AND FUNCTIONS OF IGG FC-RECEPTORS IN LYMPHOCYTES-B [J].
AMIGORENA, S ;
BONNEROT, C ;
DRAKE, JR ;
CHOQUET, D ;
HUNZIKER, W ;
GUILLET, JG ;
WEBSTER, P ;
SAUTES, C ;
MELLMAN, I ;
FRIDMAN, WH .
SCIENCE, 1992, 256 (5065) :1808-1812
[6]   Essential role of CD8 palmitoylation in CD8 coreceptor function [J].
Arcaro, A ;
Grégoire, C ;
Boucheron, N ;
Stotz, S ;
Palmer, E ;
Malissen, B ;
Luescher, IF .
JOURNAL OF IMMUNOLOGY, 2000, 165 (04) :2068-2076
[7]   Crippling of CD3-ζ ITAMs does not impair T cell receptor signaling [J].
Ardouin, L ;
Boyer, C ;
Gillet, A ;
Trucy, J ;
Bernard, AM ;
Nunes, J ;
Delon, J ;
Trautmann, A ;
He, HT ;
Malissen, B ;
Malissen, M .
IMMUNITY, 1999, 10 (04) :409-420
[8]   Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells [J].
Bachmann, MF ;
Gallimore, A ;
Linkert, S ;
Cerundolo, V ;
Lanzavecchia, A ;
Kopf, M ;
Viola, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (10) :1521-1529
[9]   Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: Implications for TCR signaling [J].
Baker, BM ;
Gagnon, SJ ;
Biddison, WE ;
Wiley, DC .
IMMUNITY, 2000, 13 (04) :475-484
[10]   αβ T cell receptor ligand-specific oligomerization revisited [J].
Baker, BM ;
Wiley, DC .
IMMUNITY, 2001, 14 (06) :681-692