Distributed neural system for general intelligence revealed by lesion mapping

被引：197

作者：

Glaescher, J. ^{[1
,2
]}

Rudrauf, D. ^{[3
,4
]}

Colom, R. ^{[5
]}

Paul, L. K. ^{[1
]}

Tranel, D. ^{[3
]}

Damasio, H. ^{[6
,7
]}

Adolphs, R. ^{[1
,8
]}

机构：

[1] CALTECH, Div Humanities & Social Sci, Pasadena, CA 91125 USA

[2] Univ Med Ctr Hamburg Eppendorf, Dept Syst Neurosci, D-20246 Hamburg, Germany

[3] Univ Iowa, Dept Neurol, Iowa City, IA 52242 USA

[4] Univ Iowa, Lab Brain Imaging & Cognit Neurosci, Iowa City, IA 52242 USA

[5] Univ Autonoma Madrid, E-28049 Madrid, Spain

[6] Univ So Calif, Dornsife Cognit Neurosci Imaging Ctr, Los Angeles, CA 90089 USA

[7] Univ So Calif, Brain & Creat Inst, Los Angeles, CA 90089 USA

[8] CALTECH, Div Biol, Pasadena, CA 91125 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 10期

基金：

美国国家卫生研究院;

关键词：

lesion patients; voxel-based lesion-symptom mapping; Wechsler Adult Intelligence Scale; white matter; AGE DEDIFFERENTIATION HYPOTHESIS; ANTERIOR PREFRONTAL CORTEX; WORKING-MEMORY; GRAY-MATTER; P-FIT; BRAIN; INTEGRATION; MECHANISMS; FLUID;

D O I：

10.1073/pnas.0910397107

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

General intelligence (g) captures the performance variance shared across cognitive tasks and correlates with real-world success. Yet it remains debated whether g reflects the combined performance of brain systems involved in these tasks or draws on specialized systems mediating their interactions. Here we investigated the neural substrates of g in 241 patients with focal brain damage using voxel-based lesion-symptom mapping. A hierarchical factor analysis across multiple cognitive tasks was used to derive a robust measure of g. Statistically significant associations were found between g and damage to a remarkably circumscribed albeit distributed network in frontal and parietal cortex, critically including white matter association tracts and frontopolar cortex. We suggest that general intelligence draws on connections between regions that integrate verbal, visuospatial, working memory, and executive processes.

引用

页码：4705 / 4709

页数：5

共 56 条

[1]

Abdi H, 2007, Encyclopedia of measurement and statistics, P849

[2] Selection, integration, and conflict monitoring: Assessing the nature and generality of prefrontal cognitive control mechanisms [J].