Synthesis and Characterization of 2-(2′-hydroxy-5′-chlorophenyl)-6-chloro-4(3H)-Quinazolinone-Based Fluorogenic Probes for Cellular Imaging of Monoamine Oxidases

被引：52

作者：

Aw, Junxin ^{[1
]}

Shao, Qing ^{[1
]}

Yang, Yanmei ^{[1
]}

Jiang, Tingting ^{[1
]}

Ang, Chungyen ^{[1
]}

Xing, Bengang ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2010年 / 5卷 / 06期

关键词：

cellular imaging; enzymes; fluorogenic probes; monoamine oxidases; quinazolinones; BETA-GLUCURONIDASE; FLUORESCENT-PROBES; MAO-A; DERIVATIVES; REPORTERS; MECHANISM; SUBSTRATE; ASSAY; GENE; PC12;

D O I：

10.1002/asia.201000025

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Monoamine oxidases (MAOs) catalyze the oxidative deamination of neuro-transmitters and biogenic amines. A new class of activity-based fluorescent probes based on the alkylation of 2-(2'-hydroxyphenyl)-4(3 H)-quinazolinone (HPQ) with primary, secondary, or tertiary amines is presented for real-time imaging of MAO activity in living cells. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1317 / 1321

页数：5

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