Efficient synthesis of a new, highly versatile chiral derivatizing agent, α-cyano-α-fluoro-p-tolylacetic acid (CFTA)

被引：39

作者：

Takeuchi, Y

Konishi, M

Hori, H

Takahashi, T

Kometani, T

Kirk, KL

机构：

[1] Toyama Med & Pharmaceut Univ, Toyama 93001, Japan

[2] Toyama Natl Coll Technol, Toyama 939, Japan

[3] NIDDK, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 03期

关键词：

D O I：

10.1039/a707755f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The new and versatile chiral derivatizing agent, alpha-cyano-alpha-fluoro-p-tolylacetic acid (CFTA), has been efficiently synthesized in optically pure form by Candida rugosa lipase-mediated kinetic resolution of racemic CFTA ethyl ester, the latter being readily prepared by fluorination of ethyl alpha-cyano-p-tolylacetate with FClO3.

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页码：365 / 366

页数：2

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