Dimerization of human growth hormone in the presence of metal ions

被引：24

作者：

Dienys, G

Sereikaitè, J

Luksa, V

Jarutiene, O

Mistiniene, E

Bumelis, VA

机构：

[1] Inst Biotechnol, LT-2028 Vilnius, Lithuania

[2] Vilnius State Univ, Fac Chem, Vilnius, Lithuania

来源：

BIOCONJUGATE CHEMISTRY | 2000年 / 11卷 / 05期

关键词：

D O I：

10.1021/bc990112j

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Zn2+ and Co2+ ions are known to promote human growth hormone reversible dimerization. In these studies, dimerization was also shown to be initiated by nine other metal ions: Cd2+, Hg2+, Cu2+, Ag+, Au3+, Auf, Pd2+, Ni2+, and Pt4+. In same cases (Hg2+, Ag+, Au3+, and Ni2+) formation of higher oligomers also took place. In addition further detailed investigation of dimerization in the presence of Zn2+ ions was carried out.

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收藏

页码：646 / 651

页数：6

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